Multicentric Castleman's disease: from the common to the unusual. Clinical case.
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Abstract
We present the case of a 49-year-old patient who debuted with B symptoms, neurological involvement, diffuse lymphadenopathy, and autoimmune hemolytic anemia due to hot antibodies. With a wide differential diagnosis, an accessible axillary adenopathy biopsy was performed, reaching the histological diagnosis of Multicenter Castleman's disease with the presence of DNA from human herpes virus type 8 in plasma determined by quantitative PCR. The patient was managed with systemic chemotherapy composed of rituximab, liposomal doxorubicin, cyclophosphamide, vincristine and dexamethasone with excellent therapeutic response.
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